Foldit的200,000多名用户面临着设计一种有助于抵抗致命病毒的蛋白质的挑战。研究人员转向视频游戏来应对冠状病毒在新的冠状病毒扩散之前，这种冠状病毒已经夺走了 全球3,000多人的生命 ，一群美国研究人员建议通过名为Foldit的视频游戏寻求针对SARS-CoV-2的补救措施。
Foldit's more than 200,000 users face the challenge of designing a protein that helps fight deadly viruses. Researchers turn to video games to deal with coronaviruses, which have claimed the lives of more than 3,000 people around the world before the spread of the new coronavirus, a group of U.S. researchers have suggested seeking SARS-CoV- 2 remedies.
Developed 12 years ago by a team of programmers and biochemists at the University of Washington in Seattle, it is an experimental computer game in which users must predict the three-dimensional structure of a protein and the folding of its amino acid sequence.
The first 3D picture of the coronavirus atomic structure paves the way for the development of vaccines. Protein is an essential component of the activity of each cell of an organism and its folding mode, that is, its stable state is reached, which determines how it will Functions performed, whether it is processing food or acting as a catalyst for chemical processes or sending signals to the brain that controls the body.
Due to the high variability of protein folding, research in this area is both expensive and time-consuming, so researchers have developed video games as a mechanism to involve more people in solving these problems. Because proteins are key to the structure of many diseases, They are usually part of the remedy.
SARS-CoV-2 is a virus that caused covid-19 pneumonia that originated in Wuhan, China last December. It belongs to the coronavirus family. It has a "spike" protein on the surface. Proteins infect human cells and multiply.
"In recent weeks, the structure of the new coronavirus spike protein and its binding to human receptors have been identified. If we manage to design a protein that binds to the coronavirus spike protein, it may play a role in blocking humans The role of cellular interactions and stop the infection, "announced on the Foldit website.
As explained in a tweet, the game's developers have more than 200,000 users, and the most promising solution will be produced and tested at the Protein Design Institute in Seattle.