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发布时间:研究人员转向视频游戏来应对冠状病毒



Foldit的200,000多名用户面临着设计一种有助于抵抗致命病毒的蛋白质的挑战。研究人员转向视频游戏来应对冠状病毒在新的冠状病毒扩散之前,这种冠状病毒已经夺走了 全球3,000多人的生命  ,一群美国研究人员建议通过名为Foldit的视频游戏寻求针对SARS-CoV-2的补救措施。

由西雅图华盛顿大学的程序员和生物化学家团队于12年前开发,它是一种实验性计算机游戏,用户必须在其中预测蛋白质的三维结构及其氨基酸序列的折叠。

冠状病毒原子结构的第一个3D图为疫苗的开发铺平了道路蛋白质是生物每个细胞活动及其折叠方式必不可少的组成部分,即达到其稳定状态,决定了它在生物体中将履行的功能,无论是加工食物还是在其中充当催化剂化学过程或向控制身体的大脑发送信号。

由于蛋白质折叠的高度可变性,在这一领域的研究既昂贵又费时,因此研究人员开发了电子游戏作为一种机制,使更多的人参与解决这些难题由于蛋白质是许多疾病结构的关键,因此它们通常是补救措施的一部分。

SARS-CoV-2是去年12月起源于中国武汉的引起covid-19肺炎的病毒,属于冠状病毒家族,其表面具有“尖峰”蛋白,该蛋白与强烈感染人细胞的受体蛋白,病毒通过该蛋白感染人细胞并繁殖。

“最近几周,人们确定了新的冠状病毒刺突蛋白的结构及其与人类受体的结合。如果我们设法设计一种与冠状病毒刺突蛋白结合的蛋白,它可能起到阻断与人类细胞相互作用的作用。并停止感染,”  在Foldit网站上宣布。

正如在一条推文中所解释的那样,该游戏的开发者拥有超过200,000的用户,最有前途的解决方案将在西雅图的蛋白质设计研究所进行生产和测试。

Foldit's more than 200,000 users face the challenge of designing a protein that helps fight deadly viruses. Researchers turn to video games to deal with coronaviruses, which have claimed the lives of more than 3,000 people around the world before the spread of the new coronavirus, a group of U.S. researchers have suggested seeking SARS-CoV- 2 remedies.

Developed 12 years ago by a team of programmers and biochemists at the University of Washington in Seattle, it is an experimental computer game in which users must predict the three-dimensional structure of a protein and the folding of its amino acid sequence.

The first 3D picture of the coronavirus atomic structure paves the way for the development of vaccines. Protein is an essential component of the activity of each cell of an organism and its folding mode, that is, its stable state is reached, which determines how it will Functions performed, whether it is processing food or acting as a catalyst for chemical processes or sending signals to the brain that controls the body.

Due to the high variability of protein folding, research in this area is both expensive and time-consuming, so researchers have developed video games as a mechanism to involve more people in solving these problems. Because proteins are key to the structure of many diseases, They are usually part of the remedy.

SARS-CoV-2 is a virus that caused covid-19 pneumonia that originated in Wuhan, China last December. It belongs to the coronavirus family. It has a "spike" protein on the surface. Proteins infect human cells and multiply.

"In recent weeks, the structure of the new coronavirus spike protein and its binding to human receptors have been identified. If we manage to design a protein that binds to the coronavirus spike protein, it may play a role in blocking humans The role of cellular interactions and stop the infection, "announced on the Foldit website.

As explained in a tweet, the game's developers have more than 200,000 users, and the most promising solution will be produced and tested at the Protein Design Institute in Seattle.
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